Oxford Genetics, a leader in synthetic biology, is a specialised contract research organisation offering services to support the discovery, development and production of biologics, with a particular focus on viral vectors for gene therapy applications. A unifying theme across the portfolio is expertise in DNA design, expression system optimisation, cell line development and engineering of viral delivery systems. We are located within purpose-fitted laboratories at the Oxford Science Park, just South of Oxford.
We are in a phase of rapid expansion and are seeking highly motivated and enthusiastic scientists and engineers to join the team and help facilitate the next stage of our development as a company. We aim to be both innovative and entrepreneurial in everything we do – join us and contribute to this exciting journey!
The Scientist – Analytical Sciences will be involved in a range of internal platform development and commercial projects, predominantly focused on establishing analytical processes and methodology for protein and viral vector-based biotherapeutics. Oxford Genetics has a number of on-going programmes in this area, and multiple government supported grant awards, which the recipient will contribute towards. This will be a predominantly lab-based position and will work closely with the Cell Line Development and Process Development teams to define and design projects. An ability to rapidly assimilate information and to learn new techniques and approaches is essential, as is high-level attention to detail and scientific rigour.
Experience in developing multiple analytical techniques and authoring SOPs is absolutely required. Relevant techniques include qPCR, ELISA, Western blotting, SPR and HPLC (Affinity, SEC). Knowledge of automation approaches for analytical methods, and implementation of sample tracking systems is particularly desirable.
- Work closely with colleagues and collaborators to define project goals and deliverables, in line the planned project objectives
- To maintain standards in the laboratories, and to contribute to ensuring best practice
- Provide project summaries and reporting, as required
- To help in establishing SOPs and methods, and in utilizing the internal LIMS system
- Promote and suggest implementation of new methods, technologies and processes
- Support line manager in ensuring smooth running of the group.
- To adhere strictly to established quality standards, essential for on-going activities
- Provide accurate record keeping at all times
MINIMUM QUALIFICATIONS OR EXPERIENCE NEEDED:
- Ph.D or MSc. with relevant laboratory experience, ideally in a commercial/industry setting.
PREFERRED SKILLS AND ABILITIES:
- Use of qPCR for quantitation of viral particles (ideally in a regulated environment)
- Development and testing of ELISAs against novel proteins, and process automation
- Western blotting, including use of capillary-based systems
- Use of SPR or QCM techniques for measuring protein binding kinetics
- HPLC for analysis of both proteins and viral vectors (including, but not limited to antibodies, antibody-fragments, Lentivirus, AAV)
- An engineering mindset – good ability to utilize statistical approaches to optimize processes and procedures
Job Type: Permanent
Hours: Full time
Salary: £28,000 – 38,000 per annum, dependent on experience
25 days Annual Leave plus Bank Holidays, Pension with matched employer contribution to 7%, Health Insurance, Group Life Cover, Child Care Voucher Scheme, Glasses Vouchers and a friendly working environment in a small and expanding company.
We have offices in the UK and USA. This role will be located at The Oxford Science Park, just 4 miles south east of Oxford, with parking and good public transport links from Oxford. Our UK office address is: Oxford Genetics Ltd, Medawar Building, The Oxford Science Park, Oxford, OX4 4GA.
HOW TO APPLY
Candidates must be eligible to work in the United Kingdom without sponsorship.
Please send a CV. Your CV should include evidence that demonstrates how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks. Your application will be judged on the basis of how you demonstrate that you meet the selection criteria stated in the job description.
DIVERSITY AND EQUALITY OF OPPORTUNITY
We provide all our staff with a welcoming and inclusive workplace that enables and empowers everyone to develop and deliver professional excellence. We recognise diversity is vital for innovation and creativity and value each individual’s contribution. Entry into employment with Oxford Genetics and further progression will be determined by personal merit and the application of criteria related to the duties of the role. The ability to perform the role will be the primary consideration on entry into employment and to successfully pass probation.
PRE EMPLOYMENT SCREENING
The appointment of the successful candidate will be subject to standard pre-employment screening, as applicable to the post. This will include right-to-work in the UK, proof of identity, references and health assessment.